| Histopathologic changes are not specific for diagnosis of gastric antral vascular ectasia (GAVE) syndrome: a review of the pathogenesis and a comparative image analysis morphometric study of GAVE syndrome and gastric hyperplastic polyps. | |
| | |
MedLine Citation:
|
PMID: 9576573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the nonspecific nature of the histologic findings in the gastric antral vascular ectasia (GAVE) syndrome by using a morphometric comparison with common gastric lesions including hyperplastic polyps and gastritis. Five clinicopathologically confirmed cases of GAVE syndrome and 41 cases of gastric hyperplastic polyps were diagnosed during a 5-year interval at Summa Health Systems (Akron, Ohio). These cases, as well as 16 randomly selected cases of nonspecific gastritis and 9 normal gastric antral biopsy specimens, were evaluated. A semiquantitative comparison of the light microscopic findings believed to be essential in diagnosis of GAVE syndrome, including vascular hyperplasia, mucosal vascular ectasia, intravascular fibrin thrombi, and fibromuscular hyperplasia, was performed. Image analysis morphometric measures of the area ratio (vascular area/total biopsy area), mean vascular area, and number of ectatic vessels per square millimeter of tissue were performed on the CAS 200 Image Analyzer (Becton Dickinson, San Jose, Calif). By morphometric and statistical parametric analysis, several histopathologic variables, including area ratio, mean vascular area, mucosal vascular ectasia, and fibromuscular hyperplasia, did not confidently differentiate the histologic features of gastric hyperplastic polyp from those of GAVE syndrome, but did apparently differentiate GAVE syndrome from gastritis and normal gastric mucosa. The propensity of gastric hyperplastic polyps to undergo prolapse changes and prolapse as one proposed mechanism for development of the GAVE syndrome lesion probably accounts for this morphologic similarity. Specific diagnostic histopathologic changes probably do not exist for the GAVE syndrome. |
| | |
Authors:
|
Z Vesoulis; N Naik; P Maseelall |
Related Documents
:
|
20673403 - Multiple spinal perimedullary arteriovenous fistulae associated with the parkes-weber s... 19838373 - Disc prolapse and cord contusion in a case of klippel-feil syndrome following minor tra... 482873 - Recurrent bladder papilloma in a child with cushing's syndrome. case report. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 109 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1998 May |
Date Detail:
|
Created Date: 1998-05-14 Completed Date: 1998-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 558-64 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, Akron City Hospital (Summa Health Systems), Ohio 44304, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biopsy Blood Vessels / pathology Female Gastric Mucosa / blood supply Gastritis / pathology Gastroscopy Humans Hyperplasia Male Middle Aged Muscle, Smooth, Vascular / pathology Polyps / pathology Pyloric Antrum / blood supply* Stomach Neoplasms / pathology Syndrome Vascular Diseases / diagnosis, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of esophageal cytology using a neural net-based interactive scanning system (the PAPNET s...
Next Document: Genetic changes associated with primary Merkel cell carcinoma.