Document Detail

Histopathologic Validation of the Intravascular Ultrasound Diagnosis of Calcified Coronary Artery Nodules.
MedLine Citation:
PMID:  21872195     Owner:  NLM     Status:  Publisher    
A calcified nodule is a type of potentially vulnerable plaque accounting for approximately 2% to 7% of coronary events. Because its intravascular ultrasound (IVUS) features have never been validated, the aim of this study was to assess the IVUS characteristics of calcified nodules in comparison to histopathology. IVUS was performed in 856 pathologic slices in 29 coronary arteries (11 left anterior descending, 5 left circumflex, and 13 right coronary arteries) in 18 autopsy hearts. Pathologic sections were analyzed every 2 mm; qualitative and quantitative findings of matched IVUS were analyzed. IVUS detected calcification in 285 frames; 17 (6.0%) were calcified nodules, and 268 (94.0%) were non-nodular calcium by histopathology. Two calcified nodules (11.8%) were solitary, and 15 (88.2%) were adjacent to non-nodular calcium. IVUS characteristics of calcified nodules were (1) a convex shape of the luminal surface (94.1% in calcified nodules vs 9.7% in non-nodular calcium, p <0.001), (2) a convex shape of the luminal side of calcium (100% vs 16.0%, p <0.001), (3) an irregular luminal surface (64.7% vs 11.6%, p <0.001), and (4) an irregular leading edge of calcium (88.2% vs 19.0%, p <0.001). Luminal area at the calcified nodule site was larger (6.2 ± 2.4 vs 4.3 ± 1.6 mm(2), p <0.001) and plaque burden less (57 ± 6% vs 68 ± 5%, p <0.001) than at the minimum luminal area site. In conclusion, calcified nodules have distinct IVUS features (irregular and convex luminal surface) permitting their prospective identification in vivo.
Jin-Bae Lee; Gary S Mintz; Jennifer B Lisauskas; Sinan G Biro; Jun Pu; Stephen T Sum; Sean P Madden; Allen P Burke; James Goldstein; Gregg W Stone; Renu Virmani; James E Muller; Akiko Maehara
Related Documents :
10550185 - Cyclic nucleotides and production of prostanoids in human varicose veins.
25148795 - First reported revascularization of complex occlusion of the right coronary artery usin...
25457295 - Ovarian vein diameter cannot be used as an indicator of ovarian venous reflux.
25195705 - Transapical endovascular repair with a table-tailored endograft to treat ascending aort...
25175135 - Severe pulmonary hypertension in adult pulmonary langerhans cell histiocytosis: the eff...
16549345 - Investigating suspected pulmonary embolism during pregnancy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-25
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prognostic Significance of Valvuloarterial Impedance and Left Ventricular Longitudinal Function in A...
Next Document:  A Variant Upstream of the CDH13 Adiponectin Receptor Gene and Metabolic Syndrome in Swedes.