Document Detail


Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region: A Multicenter Analysis.
MedLine Citation:
PMID:  22588068     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This tumor shares morphologic features with both ependymomas and choroid plexus tumors. PTPR is characterized by an epithelial-like growth pattern in which the vessels are covered by layers of tumor cells forming perivascular pseudorosettes. These tumors exhibit various combinations of papillary and solid architecture, making the differential diagnosis of PTPR difficult to establish. We report the detailed description of the histopathologic features of a large series of PTPRs from 20 different centers and distinguish 2 subgroups of tumors with either a striking papillary growth pattern or a papillary and solid growth pattern. We highlight the findings that PTPRs have unusual vessels with multiple lumina and frequently show detachment of the border of the tumoral cells from the vascular wall. The 2 PTPR subgroups present similar clinical characteristics and immunophenotypes. We confirmed and extended the results of previous ultrastructural studies on the presence of intercellular junctions at the apical part of tumoral cells. The expression of the tight junction proteins claudin-1, claudin-2, and claudin-3 was investigated by immunohistochemistry. Claudin-1 and claudin-3, but not claudin-2, were expressed in PTPRs and in the fetal subcommissural organ, potentially the origin of this tumor. In contrast, all 3 claudins were expressed in choroid plexus papillomas. Claudin expression may help in the diagnosis of PTPRs and can be used in combination with other markers, such as CK18, NCAM, E-cadherin, MAP-2, and Kir 7.1.
Authors:
Michelle Fèvre Montange; Alexandre Vasiljevic; Anne-Marie Bergemer Fouquet; Michèle Bernier; Jacques Champier; Fabrice Chrétien; Dominique Figarella-Branger; Jean-Louis Kemeny; Emmanuèle Lechapt-Zalcman; Sophie Michalak; Catherine Miquel; Karima Mokthari; Isabelle Pommepuy; Isabelle Quintin Roué; Audrey Rousseau; Ghislaine Saint-Pierre; Caroline Salon; Emmanuelle Uro-Coste; Pascale Varlet; Ingrid Kratzer; Jean-François Ghersi-Egea; Anne Jouvet
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  36     ISSN:  1532-0979     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  916-928     Citation Subset:  -    
Affiliation:
*Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, Equipe Neuro-Oncologie et Neuro-Inflammation, Université de Lyon, Lyon Cedex 08 †Service de Pathologie et de Neuropathologie, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron Cedex ‡Service d'Anatomie et de Cytologie Pathologiques, Hôpital Bretonneau, Tours Cedex §Service d'Anatomie et de Cytologie Pathologiques, Hôpital Foch, Suresnes Cedex ∥Service d'Anatomie et de Cytologie Pathologiques, Groupe Hospitalier Henri Mondor-Albert Chenevier, INSERM U955, Université Paris 12 Val-de-Marne, Creteil ¶Service d'Anatomie Pathologique et de Neuropathologie, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, CRO2 UMR 911, Aix-Marseille Université, Marseille Cedex #Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire Gabriel-Montpied, Clermont Ferrand **Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire Côte de Nacre, Caen Cedex ††Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire, Angers Cedex ‡‡Service de Neuropathologie, Centre Hospitalier Sainte-Anne, Paris Cedex §§Service de Neuropathologie, Laboratoire Raymond Escourolle, Groupe Hospitalier Pitié-Salpêtrière, Paris Cedex ∥∥Service d'Anatomie Pathologique, Hôpital Dupuytren, Limoges Cedex ¶¶Service d'Anatomie Pathologique, Centre Hospitalier Universitaire, Hôpital Morvan, Brest Cedex ##Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire, Angers Cedex ***Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier Universitaire, Grenoble Cedex †††Service d'Anatomie Pathologique, Hôpital Rangueil, Toulouse Cedex, France.
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