| Histone deacetylases as targets for treatment of multiple diseases. | |
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MedLine Citation:
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PMID: 23414309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HDACs (histone deacetylases) are a group of enzymes that deacetylate histones as well as non-histone proteins. They are known as modulators of gene transcription and are associated with proliferation and differentiation of a variety of cell types and the pathogenesis of some diseases. Recently, HDACs have come to be considered crucial targets in various diseases, including cancer, interstitial fibrosis, autoimmune and inflammatory diseases, and metabolic disorders. Pharmacological inhibitors of HDACs have been used or tested to treat those diseases. In the present review, we will examine the application of HDAC inhibitors in a variety of diseases with the focus on their effects of anti-cancer, fibrosis, anti-inflammatory, immunomodulatory activity and regulating metabolic disorders. |
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Authors:
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Jinhua Tang; Haidong Yan; Shougang Zhuang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 124 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2013 Jun |
Date Detail:
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Created Date: 2013-02-18 Completed Date: 2013-04-26 Revised Date: 2013-05-21 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 651-62 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation
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drug effects Antineoplastic Agents / therapeutic use* Apoptosis / genetics Autophagy / genetics Cell Cycle Checkpoints / genetics Epigenomics Fibrosis / drug therapy* Histone Deacetylase Inhibitors / therapeutic use* Histone Deacetylases / metabolism, physiology* Histones / metabolism Humans Immunity / genetics Immunomodulation / drug effects* Metabolic Diseases / drug therapy* Neoplasms / drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
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DK-071997/DK/NIDDK NIH HHS; DK-085065/DK/NIDDK NIH HHS; R01 DK085065/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Histone Deacetylase Inhibitors; 0/Histones; EC 3.5.1.98/Histone Deacetylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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