| Histone deacetylase inhibitors in the generation of the anti-tumour immune response. | |
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MedLine Citation:
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PMID: 22064708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acetylation of lysine residues acts to modify the function of a wide range of proteins. In histones, it affects chromatin structure, which can impact gene transcription, whereas acetylation of transcription factors and heat-shock proteins affect their activity. Deacetylase inhibitors block the dynamic turnover of acetylation resulting in hyperacetylation of target proteins. This can affect a wide range of cellular functions, and in a wide range of tumour cell types promote cytostatic and cytotoxic effects, but has little effect on normal cells. The inhibitors are being used clinically as anti-cancer agents. Although direct effects of the histone deacetylase (HDAC) inhibitors on cancers are beginning to be elucidated, the prospect of concurrent stimulation of the immune response raises hopes for immune attack of the tumour as part of the initial anti-cancer therapy and long-term immune-surveillance of residual or recurrent tumour. This review will examine the evidence for the generation of anti-tumour immunity after treatment of cancers with HDAC inhibitors.Immunology and Cell Biology advance online publication, 8 November 2011; doi:10.1038/icb.2011.94. |
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Authors:
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Graham R Leggatt; Brian Gabrielli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-08 |
Journal Detail:
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Title: Immunology and cell biology Volume: - ISSN: 1440-1711 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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