Document Detail


Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells.
MedLine Citation:
PMID:  21862211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified the molecular target by histone deacetylase (HDAC) inhibitors for exploring their potential prostate cancer (PCa) therapy. Upon HDAC inhibitors-treatment, LNCaP cell growth was suppressed, correlating with increased cellular prostatic acid phosphatase (cPAcP) expression, an authentic protein tyrosine phosphatase. In those cells, ErbB-2 was dephosphorylated, histone H3/H4 acetylation and methylation increased and cyclin proteins decreased. In PAcP shRNA-transfected C-81 cells, valproic acid (VPA) efficacy of growth suppression was diminished. Further, VPA pre-treatment enhanced androgen responsiveness of C-81, C4-2 and MDA PCa2b-AI cells. Thus, cPAcP expression is involved in growth suppression by HDAC inhibitors in PCa cells, and VPA pre-treatments increase androgen responsiveness.
Authors:
Yu-Wei Chou; Nagendra K Chaturvedi; Shougiang Ouyang; Fen-Fen Lin; Dharam Kaushik; Jue Wang; Isaac Kim; Ming-Fong Lin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-22
Journal Detail:
Title:  Cancer letters     Volume:  311     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-09-29     Completed Date:  2011-11-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  177-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. mlin@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology
Blotting, Northern
Blotting, Western
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Separation
Flow Cytometry
Histone Deacetylase Inhibitors / pharmacology*
Humans
Male
Phosphorylation
Prostatic Neoplasms / metabolism*
Protein Tyrosine Phosphatases / biosynthesis*
Receptor, erbB-2 / metabolism
Valproic Acid / pharmacology*
Grant Support
ID/Acronym/Agency:
2R01CA88184/CA/NCI NIH HHS; R01 CA088184-10/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Histone Deacetylase Inhibitors; 99-66-1/Valproic Acid; EC 2.7.10.1/Receptor, erbB-2; EC 3.1.3.2/prostatic acid phosphatase; EC 3.1.3.48/Protein Tyrosine Phosphatases
Comments/Corrections

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