Document Detail


Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
MedLine Citation:
PMID:  21331099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly.
Authors:
Astrid Spannhoff; Yong Kee Kim; Noel J-M Raynal; Vazganush Gharibyan; Ming-Bo Su; Yue-Yang Zhou; Jia Li; Sabrina Castellano; Gianluca Sbardella; Jean-Pierre J Issa; Mark T Bedford
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-18
Journal Detail:
Title:  EMBO reports     Volume:  12     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-03     Completed Date:  2011-09-16     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Affiliation:
Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bees / genetics,  growth & development,  metabolism,  physiology*
DNA Methylation
Epigenesis, Genetic*
Fatty Acids / metabolism*
Fatty Acids, Monounsaturated / chemistry,  metabolism*
Female
Hierarchy, Social
Histone Deacetylase Inhibitors / metabolism*
Insect Hormones / metabolism*
Larva / growth & development,  metabolism
Phenotype
Grant Support
ID/Acronym/Agency:
ES007784/ES/NIEHS NIH HHS; P50 CA100632/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Histone Deacetylase Inhibitors; 0/Insect Hormones; 765-01-5/10-hydroxy-2-decenoic acid; 8031-67-2/royal jelly
Comments/Corrections

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