| Histone deacetylase inhibitor, MGCD0103, synergizes with gemcitabine in human pancreatic cells. | |
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MedLine Citation:
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PMID: 21375679 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Histone deacetylase inhibitors are a group of recently developed compounds that modulate cell growth and survival. We evaluated effects of the HDAC inhibitor, MGCD0103, on growth of pancreatic carcinoma models following single agent treatment and in combination with gemcitabine. MGCD0103 inhibited tumor cell growth and acted synergistically with gemcitabine to enhance its cytotoxic effects. Gene expression analysis identified the cell cycle pathway as one of the most highly modulated gene groups. Our data suggest that MGCD0103 + gemcitabine may be an effective treatment for gemcitabine-refractory pancreatic cancer. |
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Authors:
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Victoria Sung; Normand Richard; Helen Brady; Armin Maier; Gerhard Kelter; Carla Heise |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-5 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Japanese Cancer Association. |
Affiliation:
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Celgene Corporation, 1500 Owens St. Suite 600 San Francisco, CA 94158 Celgene Corporation, 4550 Towne Centre Court San Diego, CA 92121 Oncotest GmbH, Am Flughafen 12-14 79108 Freiburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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