| Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | |
| | |
MedLine Citation:
|
PMID: 22186300 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast, autophagy precedes apoptosis and acts as a protective mechanism in the less proliferative, non N-Myc overexpressing cells. Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy. |
| | |
Authors:
|
Roser Francisco; Alba Pérez-Perarnau; Costanza Cortés; Joan Gil; Albert Tauler; Santiago Ambrosio |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-17 |
Journal Detail:
|
Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Unitat de Bioquímica, Dep. Ciències Fisiològiques II, Facultat de Medicina, Campus Universitari de Bellvitge - IDIBELL, Universitat de Barcelona, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidental and other indeterminate adrenal masses.
Next Document: Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for ora...