| Histone chaperones in nucleosome assembly and human disease. | |
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MedLine Citation:
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PMID: 23288364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field. |
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Authors:
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Rebecca J Burgess; Zhiguo Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature structural & molecular biology Volume: 20 ISSN: 1545-9985 ISO Abbreviation: Nat. Struct. Mol. Biol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-04 Completed Date: 2013-02-25 Revised Date: 2013-03-08 |
Medline Journal Info:
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Nlm Unique ID: 101186374 Medline TA: Nat Struct Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 14-22 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Proteins
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genetics,
metabolism Chromatin Assembly and Disassembly DNA Replication* Genomic Instability Histone Chaperones / metabolism* Histones / genetics, metabolism Humans Neoplasms / genetics, metabolism* Nucleosomes / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM72719/GM/NIGMS NIH HHS; GM81838/GM/NIGMS NIH HHS; GM99722/GM/NIGMS NIH HHS; R01 GM081838/GM/NIGMS NIH HHS; R01 GM099722/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Histone Chaperones; 0/Histones; 0/Nucleosomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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