Document Detail


Histone chaperones in nucleosome assembly and human disease.
MedLine Citation:
PMID:  23288364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.
Authors:
Rebecca J Burgess; Zhiguo Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature structural & molecular biology     Volume:  20     ISSN:  1545-9985     ISO Abbreviation:  Nat. Struct. Mol. Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-02-25     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101186374     Medline TA:  Nat Struct Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle Proteins / genetics,  metabolism
Chromatin Assembly and Disassembly
DNA Replication*
Genomic Instability
Histone Chaperones / metabolism*
Histones / genetics,  metabolism
Humans
Neoplasms / genetics,  metabolism*
Nucleosomes / metabolism*
Grant Support
ID/Acronym/Agency:
GM72719/GM/NIGMS NIH HHS; GM81838/GM/NIGMS NIH HHS; GM99722/GM/NIGMS NIH HHS; R01 GM072719/GM/NIGMS NIH HHS; R01 GM081838/GM/NIGMS NIH HHS; R01 GM099722/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Histone Chaperones; 0/Histones; 0/Nucleosomes
Comments/Corrections

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