Document Detail

Histone Variants and Transcription Regulation.
MedLine Citation:
PMID:  23150257     Owner:  NLM     Status:  Publisher    
Histones are the protein components of chromatin and are important for its organization and compaction. Although core histones are exclusively expressed during S phase of the cell cycle, there exist variants of canonical histones that are expressed throughout the cell cycle. These histone variants are often deposited at defined regions of the genome and they play important roles in a variety of cellular processes, such as transcription regulation, heterochromatin formation and DNA repair. In this chapter, we will focus on several histone variants that have been linked to transcription regulation, and highlight their physical and functional features that facilitate their activities in this context.
Cindy Law; Peter Cheung
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Publication Detail:
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  61     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  319-341     Citation Subset:  -    
Ontario Cancer Institute, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.
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