Document Detail

Histomorphometric examination of long-term changes in temporomandibular joints after mandibular lengthening by distraction osteogenesis in rabbits.
MedLine Citation:
PMID:  22676985     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of this study was to evaluate long-term histomorphometric changes in temporomandibular joints (TMJs) of rabbits after mandibular distraction osteogenesis (DO).
STUDY DESIGN: Twenty-six rabbits were used in this study. Two of them served as control subjects, and the remaining 24 underwent DO procedures in their left mandibular bodies. After a latency period of 5 days, 5 mm lengthening was performed at a rate of 1 mm/d. The rabbits in the experimental group were randomly divided into 4 subgroups and killed after 1, 2, 4, and 6 months. TMJs from both sides were harvested and prepared with hematoxylin and eosin stain for histomorphometric examination under an optical microscope.
RESULTS: Compared with control subjects and nondistracted sides, fibrous articular, proliferative, and hypertrophic areas were significantly increased (P < .05) in the first 2 months in distracted sides. The changes were insignificant in the fourth and sixth postoperative months.
CONCLUSION: Unilateral mandibular distraction of 5 mm was found to be well tolerated and no degenerative changes were observed histologically in the rabbit TMJs in the long-term period.
Ahmet Mihmanlı; Doğan Dolanmaz; Hakan Tüz; Alper Pampu; Hasan Hüseyin Dönmez
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Publication Detail:
Type:  Journal Article     Date:  2012-04-12
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  113     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  600-3     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Asistant Professor, Department of Oral and Maxillofacial Surgery, Dentistry Faculty, Bezmialem Vakif University, Istanbul, Turkey.
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