| Histomorphologic and immunophenotypic analysis of fibrofolliculomas and trichodiscomas in Birt-Hogg-Dube syndrome and sporadic disease. | |
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MedLine Citation:
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PMID: 12358810 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Fibrofolliculomas and trichodiscomas are benign dermal neoplasms that likely derive from the mantle of the hair follicle and can occur sporadically or in association with Birt-Hogg-Dube syndrome (BHDS). Little is known about the pathogenesis and immunophenotypic properties of these entities. METHODS: We investigated the histomorphologic and immnophenotypic properties of 15 fibrofolliculomas and trichodiscomas in two patients with BHDS and eight with sporadic disease. RESULTS: We found the following: (1) fibrofolliculomas and trichodiscomas occurring in the setting of BHDS show microscopically contiguous histomorphologic features as compared to those occurring sporadically; (2) the immunophenotypic characteristics of syndromic-associated and sporadic types are identical and consist of (3) perifollicular vimentin (+), CD34 (+) and Factor XIII (-) spindle cells. CONCLUSIONS: Despite subtle histomorphologic differences, trichodiscomas and fibrofolliculomas are immunophenotypically similar, and are thus likely derived from a similar histogenic precursor. Given the previously reported CD34 (+) immunophenotype of the hair mantle, our findings would support an origin of these lesions from the mantle of the hair follicle. The proliferation of CD34 (+) spindle cells seen in conjunction with these lesions should not be confused with other CD34 (+) dermal entities. |
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Authors:
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Gary L Collins; Stephen Somach; Michael B Morgan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 29 ISSN: 0303-6987 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-02 Completed Date: 2003-04-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 529-33 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA. gcollins@hsc.usf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Fibroma / chemistry, pathology* Hair Diseases Hair Follicle / chemistry, pathology Humans Immunohistochemistry Immunophenotyping Male Middle Aged Neoplasm Proteins / analysis Neoplasms, Multiple Primary / chemistry, pathology* Skin Neoplasms / chemistry, pathology* Syndrome Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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