Document Detail

Histometric assessment of renal arterioles during DOCA and post-DOCA hypertension and hydralazine treatment in rats.
MedLine Citation:
PMID:  2708816     Owner:  NLM     Status:  MEDLINE    
It is now well established that structural changes in resistance vessels contribute to the long-term maintenance of many forms of hypertension. This study measured the time course of structural change in smaller resistance vessels during the development of deoxycorticosterone acetates (DOCA) hypertension and after cessation of DOCA in Wistar rats by histometric assessment of cross-sections of renal arterioles. The relationship of structural change to blood pressure was assessed by preventing hypertension during DOCA treatment with hydralazine. Blood pressure rose progressively during DOCA treatment reaching 192 +/- 3 mmHg compared with 132 +/- 2 mmHg in controls after 10 weeks. Five and 10 weeks after cessation of DOCA, following 10 weeks of DOCA treatment, post-DOCA reversal of hypertension was only partial. Medial area to internal elastic lamina (IEL) radius ratio, wall to lumen ratio and intimal area to IEL radius ratio of renal arterioles increased progressively during 10 weeks of DOCA treatment with partial reversal of the increased medial area and wall to lumen ratio 5 weeks post-DOCA. Hydralazine completely prevented hypertension in DOCA rats and also largely prevented structural change.
J H Vial; G W Boyd
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  7     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Department of Medicine, Clinical School, University of Tasmania, Hobart, Australia.
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MeSH Terms
Arterioles / pathology
Blood Pressure / drug effects
Hydralazine / therapeutic use*
Hypertension / chemically induced,  pathology*
Rats, Inbred Strains
Renal Artery / pathology*
Vascular Resistance
Reg. No./Substance:
64-85-7/Desoxycorticosterone; 86-54-4/Hydralazine

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