Document Detail

Histological and ultrastructural study of the intracellular behavior of indium in the testicular tissues.
MedLine Citation:
PMID:  20945463     Owner:  NLM     Status:  In-Data-Review    
Indium, a IIIA group element of the periodic chart, has many medical uses for diagnostic and clinical investigations in humans. This element is also used in industry and in nuclear fields where released streams can contaminate environment. Consequently, indium can reach humans mainly by natural ways. In this work, we attempted to study the incidence of this element on the food intake and body and testicle weights of rat, as well as the histological and the ultrastructural consequences of its presence in testicles using conventional transmission electron microscopy. Our study showed that this element induced a significant decrease in the food intake and body and testicles weights and caused necrosis and vacuolization in germinal cells. The ultrastructural observations showed the presence of electron-dense deposits characteristic of indium in the lysosomes of Leydig and Sertoli cells as well as sufferance in mitochondria of indium-treated rats. Despite the role of lysosome in the protection of living cells, by sequestration and concentration of indium in testicle cells under insoluble form, it is probable that this element has noxious effects on food intake and body and testicles weight and induces necrosis on seminal tissues of treated rats. Microsc. Res. Tech., 2010. © 2010 Wiley-Liss, Inc.
Maghraoui Samira; Ayadi Ahlem; Ben Ammar Aouatef; Jaafoura Mohamed Habib; Tekaya Leila
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Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  Microscopy research and technique     Volume:  74     ISSN:  1097-0029     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Physiology Laboratory, Medical School of Tunis, La Rabta, Tunis, Tunisia.
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