Document Detail


Histological study of germ cells development and apoptosis in mongolian sheep fetal ovaries.
MedLine Citation:
PMID:  17630230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian germ cells proliferate by mitosis and begin meiotic development in fetal ovaries. The aim of this study is to demonstrate the germ cell proliferation and apoptosis, and elucidated some of the key developmental events and stages in Mongolian sheep fetal ovaries. Fourty three pairs of sheep fetal ovaries at days 37-99 of gestation were collected from local slaughterhouse. Studies in histological structure of ovaries and germ cell apoptosis were achieved by employing light microscopy and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL). Following fetal gestation age increasing, three key development events were detected: oogonia fleetly proliferated by mitosis and clustered at days 37-55 of gestation in ovarian cortex forming oogonia nest; the formation of ovigerous cords (OC) and disorganization took place at day 51-81, especially at days 63-66 more OC developed, and more germ cells in OC entered meiosis prophase; subsequently, with the OC disappeared, primordial follicles gradually prevailed from day 73 of gestation. Another observation was germ cells apoptosis and the number of apoptotic germ cells showed a peak from day 58 to day 73 (P<0.05) and germ cells in OC were prone to apoptosis. The study provides evidence about histological feature and germ cells apoptosis in sheep fetal ovaries.
Authors:
Aladaer Qi; Zp Zhang; Gf Cao; Y Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-18
Journal Detail:
Title:  Animal reproduction science     Volume:  103     ISSN:  0378-4320     ISO Abbreviation:  Anim. Reprod. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807205     Medline TA:  Anim Reprod Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Affiliation:
Institution of Bio-Engineering, Northwest A & F University, Yang ling 712100, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology*
Female
Fetal Development / physiology*
Fetus
Histocytochemistry / veterinary
In Situ Nick-End Labeling / veterinary
Oogonia / physiology*
Ovary / cytology,  embryology*
Pregnancy
Sheep / embryology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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