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Histological study of the fetal development of the human acetabulum and labrum: significance in congenital hip disease.
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MedLine Citation:
PMID:  7324504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy-four acetabula from a total of 140 normal human fetuses, obtained from abortions and deaths in the prenatal period, were used. The fetuses ranged from 9.1 to 40 cm in crown-rump length and are believed to be between 12 weeks and term. Acetabula were decalcified embedded in paraffin or celloidin, sectioned, and stained using conventional histologic techniques. Sections from the superior one-quarter of the acetabulum were examined for the initial appearance and later spread of osseous tissue. Throughout the fetal period bone was present only in the floor of the acetabulum and did not extend into the socket walls. Ossification was detected initially more posteriorly in the socket floor, and at all ages, ossification was more prominent on the ischial side of the socket. Despite the lack of osseous tissue a well-formed hyaline cartilage socket was present. The fetal labrum was composed of fibrous tissue with the density of fibers increasing with age. Typical-appearing chondrocytes were detected at only the inner articular margin of the labrum. Contributing from one-fifth to one-half of the socket depth, the labrum may play a greater role in containing the femoral head at birth than it does in the mature joint. In seven acetabula, from joints that were neither subluxated nor dislocated, an area of areolar tissue with capillaries was detected at the hyaline cartilage-labrum junction. Such defects may weaken the labrum and contribute to neonatal hip instability.
Authors:
J M Walker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  54     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetabulum / blood supply,  embryology*
Female
Fetus / physiology*
Gestational Age
Hip Dislocation, Congenital / embryology
Hip Joint / blood supply,  embryology*
Humans
Male
Osteogenesis
Pregnancy
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
Journal ID (pmc): yjbm
ISSN: 0044-0086
ISSN: 1551-4056
Publisher: Yale Journal of Biology and Medicine
Article Information
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Print publication date: Season: Jul?Aug Year: 1981
Volume: 54 Issue: 4
First Page: 255 Last Page: 263
ID: 2595965
PubMed Id: 7324504

Histological study of the fetal development of the human acetabulum and labrum: significance in congenital hip disease.
J. M. Walker



Article Categories:
  • Research Article


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