Document Detail


Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery.
MedLine Citation:
PMID:  22781909     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to investigate the relationship between histological findings of the pancreatic stump and postoperative pancreatic exocrine function.
METHODS: One hundred ten patients including 80 patients undergoing pancreatoduodenectomy (PD) and 30 patients undergoing distal pancreatectomy (DP) were enrolled into this study. Postoperative exocrine pancreatic function was evaluated by C-labeled mixed triglyceride breath test. The areas of acinar cells, fibrotic tissues, and fatty replacement were histologically calculated in surgical specimens of the pancreatic stump.
RESULTS: Histologically, acinar cell area of patients undergoing PD was significantly less than that of patients undergoing DP (P = 0.025). The values of the mean percentage dose C cumulative 7 hours of patients undergoing PD were significantly lower than those of patients undergoing DP (P < 0.001). The rate of pancreatic exocrine insufficiency in patients undergoing PD is significantly higher than that in patients with DP (P = 0.002). There was a significant correlation between acinar cell area of the pancreatic stump and the percentage dose C cumulative 7 hours (R = 0.35, P < 0.001).
CONCLUSIONS: Pancreatoduodenectomy induced pancreatic exocrine insufficiency more frequently than DP. Histological loss of acinar cells in the pancreatic stump was strongly correlated with postoperative pancreatic exocrine function.
Authors:
Yoshio Yuasa; Yoshiaki Murakami; Hiroyuki Nakamura; Kenichiro Uemura; Hiroki Ohge; Takeshi Sudo; Yasushi Hashimoto; Akira Nakashima; Eiso Hiyama; Taijiro Sueda
Related Documents :
2541809 - Abnormalities in the response of plasma arginine vasopressin during hypertonic saline i...
1251759 - Lithium treatment and weight gain.
10418589 - Incidence, prognosis, and etiology of end-stage liver disease in patients receiving hom...
11759979 - Impact of liver cirrhosis on nutritional and immunological status.
22323189 - Expression of dominant-negative ikaros isoforms and associated genetic alterations in c...
21722709 - Pre-screening and follow-up of childhood acute leukemia using biochemical infrared anal...
1840819 - Clinical course and diagnosis of migraine headaches in hydrocephalic children.
15556839 - Laser doppler-recorded venoarteriolar reflex in raynaud's phenomenon.
19422719 - A complementary method for detecting qi vacuity.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  41     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  928-33     Citation Subset:  IM    
Affiliation:
From the Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of a novel model of hypertriglyceridemic acute pancreatitis in hamsters: protective effe...
Next Document:  Minimizing the dependency ratio in a population with below-replacement fertility through immigration...