| Histological loss of pancreatic exocrine cells correlates with pancreatic exocrine function after pancreatic surgery. | |
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MedLine Citation:
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PMID: 22781909 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to investigate the relationship between histological findings of the pancreatic stump and postoperative pancreatic exocrine function. METHODS: One hundred ten patients including 80 patients undergoing pancreatoduodenectomy (PD) and 30 patients undergoing distal pancreatectomy (DP) were enrolled into this study. Postoperative exocrine pancreatic function was evaluated by C-labeled mixed triglyceride breath test. The areas of acinar cells, fibrotic tissues, and fatty replacement were histologically calculated in surgical specimens of the pancreatic stump. RESULTS: Histologically, acinar cell area of patients undergoing PD was significantly less than that of patients undergoing DP (P = 0.025). The values of the mean percentage dose C cumulative 7 hours of patients undergoing PD were significantly lower than those of patients undergoing DP (P < 0.001). The rate of pancreatic exocrine insufficiency in patients undergoing PD is significantly higher than that in patients with DP (P = 0.002). There was a significant correlation between acinar cell area of the pancreatic stump and the percentage dose C cumulative 7 hours (R = 0.35, P < 0.001). CONCLUSIONS: Pancreatoduodenectomy induced pancreatic exocrine insufficiency more frequently than DP. Histological loss of acinar cells in the pancreatic stump was strongly correlated with postoperative pancreatic exocrine function. |
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Authors:
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Yoshio Yuasa; Yoshiaki Murakami; Hiroyuki Nakamura; Kenichiro Uemura; Hiroki Ohge; Takeshi Sudo; Yasushi Hashimoto; Akira Nakashima; Eiso Hiyama; Taijiro Sueda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreas Volume: 41 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 928-33 Citation Subset: IM |
Affiliation:
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From the Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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