Document Detail


Histological investigation of liposuctioned fat for injection laryngoplasty.
MedLine Citation:
PMID:  15991086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: There are a few injectable biomaterials used in vocal-fold-augmentation surgery. In this study, liposuctioned autologous fat, used as the injection material, was investigated histologically. MATERIALS AND METHODS: Liposuctioned fat, which was harvested from 13 patients during injection laryngoplasty, was examined by light and electron microscopy. RESULTS: The cell membranes of most of the liposuctioned fat had not been damaged during harvesting and microinjection by our method. The harvested liposuctioned fat was a group of unilocular fat cells. Each cell was surrounded by a meshwork of fine reticular fibers. The cells were spherical and about 30 to 130 microm in diameter. The cells size and density were different from individual to individual. The diameters of liposuctioned fat cells were correlated with the body mass index. Dense and small fat cells were able to maintain graft volume. Sparse and large fat cells tended to not be able to maintain graft volume. There was little proliferation of unilocular fat cells, which were not able to maintain graft volume. CONCLUSION: The structure consisting of a unilocular cell, containing a single droplet of lipid, surrounded by a meshwork of delicate reticular fiber is one of the reasons why autologous fat has viscous properties similar to those of human lamina propria. Autologous fat was not damaged by our harvesting and microinjection method. The size, density and proliferation of fat cells, and ground substance around them may be related to resorption and a decrease in surviving graft volume.
Authors:
Kiminori Sato; Hirohito Umeno; Tadashi Nakashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  26     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-07-01     Completed Date:  2005-12-12     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, Japan. kimisato@oct-net.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / ultrastructure
Adipose Tissue / cytology*,  transplantation*,  ultrastructure
Adult
Aged
Female
Humans
Injections
Lipectomy
Male
Microscopy, Electron
Microscopy, Electron, Scanning
Microscopy, Polarization
Middle Aged
Otorhinolaryngologic Surgical Procedures / methods,  standards
Tissue Preservation
Transplantation, Autologous / methods,  standards
Vocal Cord Paralysis / etiology,  surgery*
Vocal Cords / pathology,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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