Document Detail

Histological insight into the pathogenesis of severe laryngomalacia.
MedLine Citation:
PMID:  11576629     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To correlate clinical and histological findings in patients with laryngomalacia who required surgical intervention. METHODS: Retrospective study of all patients undergoing supraglottoplasty by a single surgeon (MEG) for severe laryngomalacia between October, 1999 and November, 2000. RESULTS: Nine patients were identified, of which seven had clinical evidence of GER. Seven patients had co-existing abnormalities or delays of neuromuscular development including seizure disorder, agenesis of the corpus callosum, obstructive sleep apnea, primary aspiration, a history of apparent life-threatening events, and craniosynostosis. Varying degrees of subepithelial edema and significant dilation of the subepithelial lymphatics were noted in all specimens. Submucosal inflammation was minimal to mild, and intraepithelial inflammation was rare to absent in all sections. No submucosal gland hyperplasia was seen in the samples from any patient. Two specimens contained cuneiform cartilage, both of which were histologically characterized as fibrocartilage. CONCLUSIONS: In this series, the histopathology of tissue excised during the treatment of severe laryngomalacia was dominated by submucosal edema and lymphatic dilation. Further study is needed to investigate comorbidities that may contribute to the need for intervention in children with laryngomalacia.
R K Chandra; M E Gerber; L D Holinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  61     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-28     Completed Date:  2001-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL, USA.
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MeSH Terms
Epiglottis / surgery
Gastroesophageal Reflux / etiology
Infant, Newborn
Laryngeal Diseases / complications,  pathology*,  surgery
Laryngeal Mucosa / pathology*
Neuromuscular Diseases / complications
Respiratory Sounds / etiology
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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