Document Detail

Histological and immunohistological identification of collagens in basement membranes of Schwann cells of neurofibromas.
MedLine Citation:
PMID:  6356960     Owner:  NLM     Status:  MEDLINE    
The application of immunohistological techniques that use antibodies highly specific for collagen allows new comparative studies in the distribution and deposition of genetically distinct types of collagens in neurofibromas. The identification of collagen type IV in basement membranes is unique and marks particularly the sheaths or cytoplasma of proliferating Schwann cells. Cells with greater degrees of atypia show increased amounts of intracellular collagen in basement membranes by immunohistologic examination, which provides an additional diagnostic tool in dermatopathology.
R E Gay; S Gay; R E Jones
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  5     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-25     Citation Subset:  IM    
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MeSH Terms
Basement Membrane / metabolism
Collagen / metabolism*
Fibroma / metabolism*,  pathology
Fluorescent Antibody Technique
Neurofibroma / metabolism*,  pathology
Schwann Cells / metabolism*
Skin Neoplasms / metabolism*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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