Document Detail


Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis.
MedLine Citation:
PMID:  16274836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: While the definitive diagnosis of cirrhosis is histological, it is the degree of portal hypertension, as determined by the hepatic venous pressure gradient (HVPG), that is an important determinant of the severity of cirrhosis. An HVPG > or =10 mmHg (termed clinically significant portal hypertension or CSPH) is predictive of the development of complications of cirrhosis, including death. This study aimed to determine the relationship between specific histological parameters and HVPG in cirrhosis. METHODS: Forty-three patients with biopsy-proven cirrhosis and HVPG measurements within 6 months of the biopsy were included in the study. The following parameters were scored semiquantitatively and without knowledge of HVPG results: sinusoidal fibrosis, septal thickness, loss of portal tracts and central veins, nodule size, inflammation, steatosis, and iron. RESULTS: Septal thickness (p=0.03), small nodularity (p=0.003), loss of portal tracts (p=0.01), inflammation (p=0.04) and alcoholic etiology (p=0.01) correlated with the presence of CSPH. However, small nodularity and septal thickness were the only parameters independently predictive of CSPH (r=0.658, p<0.05). CONCLUSIONS: We describe a subclassification of histological cirrhosis based on the severity of portal hypertension that consists of a combination of nodule size and septal thickness, with small nodularity and thick septa being independent predictors of the presence of CSPH.
Authors:
Satish Nagula; Dhanpat Jain; Roberto J Groszmann; Guadalupe Garcia-Tsao
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-09-23
Journal Detail:
Title:  Journal of hepatology     Volume:  44     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Affiliation:
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Disease Progression
Female
Follow-Up Studies
Humans
Hypertension, Portal / etiology,  physiopathology
Liver / pathology*
Liver Cirrhosis / classification*,  pathology,  physiopathology
Male
Middle Aged
Prognosis
Retrospective Studies
Severity of Illness Index
Venous Pressure / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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