Document Detail

Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin).
MedLine Citation:
PMID:  17166893     Owner:  NLM     Status:  MEDLINE    
AIM: To report the findings in a patient treated by repeated intravitreal bevacizumab (Avastin) injections, followed by macular relocation and excision of subfoveal choroidal neovascular membrane (CNV).
METHODS: Histopathological evaluation of the CNV specimen, including immunohistochemical assessment.
RESULTS: During surgical excision, the CNV seemed to be avascular and its underlying bed did not bleed. Histopathological examination revealed that the CNV comprised avascular fibrous subretinal tissue containing fibroblastic retinal pigment epithelial (RPE) cells, fragments of irregular thickened Bruch's membrane and fibrotic choroidal tissue containing some medium-sized vessels but no choriocapillaris.
CONCLUSIONS: The development of an RPE tear during the course of Avastin treatment may reflect contraction of the avascular subretinal tissue, whereas the lack of capillaries in both choroidal and subretinal components may be caused by the increased access of Avastin to the choriocapillaris in the presence of the RPE tear.
S K Gibran; A Sachdev; T Stappler; R Newsome; D Wong; P Hiscott
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-12-13
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  91     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-05-24     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  602-4     Citation Subset:  IM    
St Paul's Eye Unit, Royal Liverpool Hospital, Liverpool L7 8XP, UK.
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MeSH Terms
Angiogenesis Inhibitors / administration & dosage*
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized
Choroidal Neovascularization / drug therapy*,  pathology,  surgery
Drug Administration Routes
Macular Degeneration / drug therapy*,  pathology,  surgery
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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