Document Detail

Histological features of resolving acute, non-complicated phlegmonous appendicitis.
MedLine Citation:
PMID:  10707364     Owner:  NLM     Status:  MEDLINE    
The histological features of resolving acute appendicitis are described. Formalin-fixed, paraffin-embedded appendices of 200 cases with acute, non-complicated phlegmonous appendicitis were reviewed. In 80 out of 200 cases, a histological picture characterized by a predominantly lymphocytic infiltrate of the subserosa and muscularis propria or the subserosa alone was found. In the affected muscularis propria, eosinophils were admixed with lymphocytes, and the cellular infiltrate showed a lesser degree than that of the classic phlegmonous appendicitis. A multifocal, rather than a diffuse pattern of infiltration was observed. Cases were divided into three groups. Group 1: appendices with the typical features of phlegmonous appendicitis: 120 cases, 60%. Group 2: appendices with a predominantly lymphocytic infiltrate in the muscularis propria, subserosa, or both, and no granulation tissue: 65 cases, 32.5%. Group 3: appendices with granulation tissue: 15 cases, 7.5%. Complicated appendicitis was excluded. Data on the duration of the clinical symptoms were derived from the clinical history. The differences between the mean duration time of groups 1 and 2, and of groups 2 and 3 were statistically significant. The findings support the contention that a mixed infiltrate of lymphocytes and eosinophils represents a regression phase of acute appendicitis.
S Ciani; B Chuaqui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  196     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2000  
Date Detail:
Created Date:  2000-03-23     Completed Date:  2000-03-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Department of Pathology, School of Medicine, Catholic University of Chile, Santiago, Chile.
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MeSH Terms
Acute Disease
Appendicitis / complications,  pathology*,  surgery
Appendix / cytology,  pathology*,  surgery
Cellulitis / complications,  pathology*
Child, Preschool
Eosinophils / pathology
Granulation Tissue / pathology
Lymphocytes / pathology
Middle Aged
Neutrophils / pathology
Plasma Cells / pathology
Remission, Spontaneous
Time Factors

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