Document Detail


Histological features of the nasal mucosa in hematopoietic stem cell transplantation.
MedLine Citation:
PMID:  22186237     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Immunosuppression is the leading cause of recurrent sinus infections after hematopoietic stem cell transplant (HSCT), with increased incidence of sinusitis in patients with chronic graft versus host disease (GVHD). Histological descriptions of the oral mucosa, lung ciliary epithelium, and intestinal mucosa related to HSCT have been described. However, few have described the nasal mucosa. We, therefore, sought to elucidate the histological and ultrastructural features of the nasal mucosa in patients after HSCT to better understand the pathophysiology of the immune response.
METHODS: Uncinate processes from 24 HSCT patients and 12 immunocompetent patients were subjected to histological analyses via light and transmission electron microscopy (TEM).
RESULTS: TEM revealed aberrant cilia structure, altered mitochondria quantity, microvilli, and cytoplasm vacuolization. All HSCT patients with rhinosinusitis had significant loss or absence of cilia (p = 0.018). Apoptotic bodies were increased and Goblet cells decreased in nasal epithelium from patients with chronic GVHD (p = 0.04).
CONCLUSION: This tissue destruction likely enhances pathogen penetration resulting in recurrent infection.
Authors:
Erica Ortiz; Eulália Sakano; Luciana R Meirelles; Afonso C Vigorito; Maria L Cintra; Ilma A Paschoal; Carlos T Chone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of rhinology & allergy     Volume:  25     ISSN:  1945-8932     ISO Abbreviation:  Am J Rhinol Allergy     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101490775     Medline TA:  Am J Rhinol Allergy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, UNICAMP Campinas, Sao Paulo, Brazil.
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