Document Detail

Histological evaluation of maxillary sinus mucosa after functional endoscopic sinus surgery.
MedLine Citation:
PMID:  18201454     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was performed to evaluate the histological changes of the maxillary sinus mucosa of patients with chronic rhinosinusitis (CRS) after functional endoscopic sinus surgery (FESS). METHODS: In a cohort study, biopsy specimens were collected from the maxillary sinus of patients submitted for FESS. One year after surgery, patients were clinically reassessed. Patients showing recurrence of disease (group 1) required a revision surgery, through which a second biopsy specimen was collected. Patients showing a favorable clinical response (group 2) were submitted to an outpatient maxillary biopsy through the previous opened middle meatus antrostomy. Biopsy material from four cadavers was used as control. The histological and electron microscope findings were analyzed. RESULTS: At the initial surgery, patients presented many histopathological alterations, such as an inflammatory process infiltrating the submucosa, atypical respiratory epithelium with an important increase in goblet cells, metaplasia, or mixed epithelium. Group 1 patients persisted with the same alterations 1 year later, but ciliary dysmorphy was more accentuated. Group 2 patients presented a predominantly pseudostratified epithelium, but some areas contained an increased number of goblet cells and a reduction in the number of ciliated cells. CONCLUSION: Recovery of the maxillary sinus mucosa of patients with CRS, observed by electron and light microscopy, was incomplete 1 year after endoscopic surgery, even in nonsymptomatic patients; nevertheless, these alterations were more important in symptomatic patients than in asymptomatic patients.
Wilma T Anselmo-Lima; Maria Dolores Seabra Ferreira; Fabiana Cardoso Pereira Valera; Maria Rossato; Valder Rodrigues de Mello; Ricardo Cassiano Demarco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of rhinology     Volume:  21     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-24     Citation Subset:  IM    
Department of Ophthalmology, Otorhinolaryngology , Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
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MeSH Terms
Chronic Disease
Epithelium / ultrastructure
Maxillary Sinus / pathology*,  ultrastructure
Mucous Membrane / pathology*,  ultrastructure
Nasal Polyps / surgery*
Rhinitis / pathology*
Sinusitis / pathology*
Treatment Outcome

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