Document Detail

Histological evaluation of different biodegradable and non-biodegradable membranes implanted subcutaneously in rats.
MedLine Citation:
PMID:  10958425     Owner:  NLM     Status:  MEDLINE    
Different types of biodegradable membranes have become available for guided tissue regeneration. The purpose of this study was to evaluate histologically three different biodegradable membranes (Bio-Gide, Resolut and Vicryl) and one non-biodegradable membrane (expanded polytetrafluoroethylene/e-PTFE) implanted subcutaneously in rats. Five subcutaneous pouches were created in each of 24 rats. One of the four test membranes was randomly placed in each of the four pouches and one pouch was left empty to serve as a control. Histological evaluation was performed after 4, 10 and 21 days which demonstrated that e-PTFE was well tolerated and encapsulated by a fibrous connective tissue capsule. There was capsule formation around Resolut and Vicryl and around Bio-Gide in the early phase there was a wide inflammatory zone already. e-PTFE and Vicryl were stable materials while Resolut and Bio-Gide fragmented in the early phase. In the late phase Vicryl was surrounded by an increasing amount of multinucleated macrophages and a thin capsule, whilst around Resolut and Bio-Gide a strong foreign body reaction was observed. Also granuloma formation was noted around the fragmented Resolut material in its capsule and a mild inflammatory reaction surrounding Bio-Gide within its thin capsule.
S Zhao; E M Pinholt; J E Madsen; K Donath
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery     Volume:  28     ISSN:  1010-5182     ISO Abbreviation:  J Craniomaxillofac Surg     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704309     Medline TA:  J Craniomaxillofac Surg     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  D; IM    
Institute for Surgical Research, University of Oslo, The National Hospital Rikshospitalet, Norway.
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MeSH Terms
Absorbable Implants / adverse effects
Biocompatible Materials / adverse effects
Collagen / adverse effects
Connective Tissue / pathology,  surgery
Foreign-Body Reaction / etiology*,  pathology
Implants, Experimental / adverse effects*
Membranes, Artificial*
Polyglactin 910 / adverse effects
Rats, Wistar
Skin / surgery
Reg. No./Substance:
0/Bio-Gide; 0/Biocompatible Materials; 0/Membranes, Artificial; 0/Resolut; 34346-01-5/Polyglactin 910; 9002-84-0/Polytetrafluoroethylene; 9007-34-5/Collagen

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