Document Detail

Histological evaluation of chitosan-based biomaterials used for the correction of critical size defects in rat's calvaria.
MedLine Citation:
PMID:  19536827     Owner:  NLM     Status:  MEDLINE    
Chitosan, a biopolymer obtained from chitin, and its derivates, such as chitosan hydrochloride, has been reported as wound healing accelerators and as possible bone substitutes for tissue engineering, and therefore these substances could be relevant in dentistry and periodontology. The purpose of this investigation was to make a histological evaluation of chitosan and chitosan hydrochloride biomaterials (gels) used in the correction of critical size bone defects made in rat's calvaria. Bone defects of 8 mm in diameter were surgically created in the calvaria of 50 Holtzman (Rattus norvegicus) rats and filled with blood clot (control), low molecular weight chitosan, high molecular weight chitosan, low molecular weight chitosan hydrochloride, and high molecular weight chitosan hydrochloride, numbering 10 animals, divided into two experimental periods (15 and 60 days), for each biomaterial. The histological evaluation was made based on the morphology of the new-formed tissues in defect's region, and the results indicated that there was no statistical difference between the groups when the new bone formation in the entire defect's area were compared (p > 0.05) and, except in the control groups, assorted degrees of inflammation could be seen. In conclusion, chitosan and chitosan hydrochloride biomaterials used in this study were not able to promote new bone formation in critical size defects made in rat's calvaria.
Rubens Spin-Neto; Rubens Moreno de Freitas; Cha?ne Pavone; M?rcia Barreto Cardoso; S?rgio Paulo Campana-Filho; Rosemary Adriana Chi?rici Marcantonio; Elcio Marcantonio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  93     ISSN:  1552-4965     ISO Abbreviation:  J Biomed Mater Res A     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-14     Citation Subset:  IM    
Department of Periodontology, Araraquara Dental School, S?o Paulo State University, Araraquara, S?o Paulo, Brazil.
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MeSH Terms
Biocompatible Materials / pharmacology*
Chitosan / pharmacology*
Osteogenesis / drug effects
Skull / drug effects*,  pathology*
Reg. No./Substance:
0/Biocompatible Materials; 9012-76-4/Chitosan

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