Document Detail

Histological and cytological heterogeneity of bone marrow in Philadelphia-positive chronic myelogenous leukaemia at diagnosis.
MedLine Citation:
PMID:  3478078     Owner:  NLM     Status:  MEDLINE    
Cytological and histological features of the bone marrow in Philadelphia-positive chronic myelogenous leukaemia (CML) at diagnosis were analysed in a prospective study. Formerly described (Frisch et al, 1984) subtypes GRAN and GRAN/MEG were found, and myelofibrosis and incipient blast crisis could also be detected. A more or less continuous spectrum of number and degree of atypias in megakaryocytes was found. Biopsy and imprint were complementary in making differential diagnosis of both subtypes. Cytologically, type GRAN/MEG was characterized by a mixed proliferation of neutrophil, eosinophil and basophil series, besides proliferation of megakaryocytes. Type GRAN showed a predominantly neutrophilic proliferation. The importance of performing bone marrow analysis in evaluation of CML patients is discussed.
I Lorand-Metze; J Vassallo; C A Souza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  67     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-16     Completed Date:  1987-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Department of Internal Medicine, State University of Campinas, Brazil.
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MeSH Terms
Bone Marrow / pathology*
Cell Count
Granulocytes / pathology
Leukemia, Myeloid / genetics,  pathology*
Megakaryocytes / pathology
Philadelphia Chromosome
Prospective Studies

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