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Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion.
MedLine Citation:
PMID:  21943888     Owner:  NLM     Status:  Publisher    
BACKGROUND: Microvascular obstruction after reperfusion therapy of acute myocardial infarction is reported as an adverse promoter of left ventricular remodeling and is an important target to prevent deterioration into heart failure. In this study, we illustrate the early onset of a magnetic resonance imaged microvascular obstruction in a porcine model of acute myocardial infarction with the exact histological correlate. METHODS: Occlusion of the left anterior descending coronary artery followed by 3-h reperfusion was performed in 10 pigs. Microvascular obstruction was assessed by contrast-enhanced magnetic resonance imaging (MRI). After sacrifice, serial sectioned slices of the hearts matching the MRI were stained with Triphenyl tetrazolium chloride (TTC). Biopsies were fixed, embedded in paraffin, and stained for hematoxylin-eosin. RESULTS: Microvascular obstruction was defined with MRI as a hypoenhanced no-reflow area within the hyperenhanced infarct region. Erythrocyte plugging was consistently observed in the no-reflow area and was completely absent in the adjacent hyperenhanced infarct region. CONCLUSION: This model of acute ischemia-reperfusion contributes to the histological comprehension of contrast-enhanced MRI during the early stages of myocardial infarction.
Ronald B Driesen; Jaroslaw Zalewski; Nina Vanden Driessche; Kristel Vermeulen; Jan Bogaert; Karin R Sipido; Frans Van de Werf; Piet Claus
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Publication Detail:
Type:  -     Date:  2011-9-21
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  -     ISSN:  1879-1336     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Cardiovascular Medicine, Laboratory of Experimental Cardiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium.
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