Document Detail

Histological characteristics of incidentally-found growing meningiomas.
MedLine Citation:
PMID:  23037194     Owner:  NLM     Status:  MEDLINE    
OBJECT: With the wider use of CT and MRI, many meningiomas are discovered as incidental findings during diagnostic work-up for unrelated symptoms. The majority shows no or minimal growth. The purpose of this study was to distinguish pathological features of incidentally-found growing meningiomas by comparing incidentally-found with symptomatic meningiomas.
METHODS: One hundred and thirty two consecutive non-recurrent surgically-treated meningiomas treated between 2005 and 2007 were divided into three categories: 19 incidentally-found growing meningiomas (IG), 50 incidentally-found meningiomas (I), and 63 symptomatic (S) meningiomas. The average follow-up period for the IG meningiomas was 3.7 years. Six out of 19 patients of the IG meningiomas became symptomatic during observation.
RESULTS: There is a significant difference of the incidence of WHO grades I, II, and III between all three groups (p=0.035). The incidence of WHO grades II and III in groups IG, I, and S were 26%, 2%, and 10%, respectively. We compare MIB-1 staining index between three groups: an average was 3.8% in IG, 1.3% in I, and 2.4% in S meningiomas.
CONCLUSIONS: Incidentally-found meningiomas need careful follow-up. One fourth of the meningiomas that showed signs of growing belonged to the atypical or malignant grade.
Hidetoshi Kasuya; Osami Kubo; Koichi Kato; Boris Krischek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  59     ISSN:  1349-6867     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-05-23     Revised Date:  2014-07-03    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Meningeal Neoplasms / chemistry,  pathology*
Meningioma / chemistry,  pathology*
Middle Aged
Neoplasm Grading
Ubiquitin-Protein Ligases / analysis
Reg. No./Substance:
EC ligase, human; EC Ligases

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