Document Detail

Histological characteristics of breast carcinoma in blacks and whites.
MedLine Citation:
PMID:  7519506     Owner:  NLM     Status:  MEDLINE    
Tumor characteristics of 963 newly diagnosed invasive breast cancer cases from the population-based Black/White Cancer Survival Study were evaluated. Representative slides of the tumors were requested from all participating hospitals of three metropolitan areas and reviewed by one expert pathologist, blinded in regard to the age and race of patients. Nine tumor characteristics were evaluated for black and white patients. After adjusting for age, stage, and metropolitan area, blacks were significantly more likely to have high grade nuclear atypia [odds ratio (OR) = 1.97, 95% confidence interval (CI) = 1.27-3.04]; high mitotic activity (OR = 2.05, 95% CI = 1.34-3.14), grade 3 tumors (OR = 1.58, 95% CI = 1.02-2.45), and more necrosis (OR = 1.51, 95% CI = 1.16-1.98); and less likely to have well defined tubular formation (OR = 0.57, 95% CI = 0.42-0.77), marked fibrosis (OR = 0.65, 95% CI = 0.45-0.94), and positive estrogen receptor status (OR = 0.78, 95% CI = 0.58-1.05). These black/white differences remained after controlling for socioeconomic status (SES), body mass index, use of alcohol and tobacco, reproductive experience, and health care access and utilization. No significant racial differences were found for blood vessel invasion and lymphatic invasion. Although white women of high SES had more favorable tumors than those of low SES, the same pattern was not observed for blacks. High SES black women had statistically nonsignificant elevated ORs of a high mitotic index and tumor grade. These racial differences in tumor biology may have etiological and clinical implications.
V W Chen; P Correa; R J Kurman; X C Wu; J W Eley; D Austin; H Muss; C P Hunter; C Redmond; M Sobhan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  3     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-08     Completed Date:  1994-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-35     Citation Subset:  IM    
Department of Pathology, Louisiana State University Medical Center, New Orleans 70112-1393.
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MeSH Terms
African Continental Ancestry Group*
Breast / pathology
Breast Neoplasms / etiology,  mortality,  pathology*
Confidence Intervals
European Continental Ancestry Group*
Lymphatic Metastasis
Microtubules / ultrastructure
Middle Aged
Mitotic Index
Neoplasm Staging
Neoplasms, Hormone-Dependent / etiology,  mortality,  pathology
Neovascularization, Pathologic / pathology
Odds Ratio
Receptors, Estrogen / analysis
Risk Factors
Socioeconomic Factors
Survival Rate
United States / epidemiology
Urban Population* / statistics & numerical data
Grant Support
N01-CN-45174/CN/NCI NIH HHS; N01-CN-45175/CN/NCI NIH HHS; N01-CN-45176/CN/NCI NIH HHS
Reg. No./Substance:
0/Receptors, Estrogen

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