| Histological changes in chronic experimental aneurysms surgically fashioned in sheep. | |
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MedLine Citation:
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PMID: 9423218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After experimental venous pouch saccular aneurysms were surgically fashioned on common carotid arteries of sheep, the ensuing long term hemodynamic effects on the vessel walls were examined up to seven years postoperatively. The aneurysms became more spherical rather than remaining elongated, enlarging at variable, individual rates. Venous sac changes were similar to phlebosclerosis in human veins with progression to sclerotic walls and loss of conventional mural architecture at most sites. Lipid accumulation, despite low serum cholesterol levels, calcification, intimal tears of variable depth, mural dissection and secondary mural thrombosis, occurred as in human atherosclerosis and indicated this model's potential for studies of such pathological disorders and the pathological effects of enhanced hemodynamic stress. |
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Authors:
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W E Stehbens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pathology Volume: 29 ISSN: 0031-3025 ISO Abbreviation: Pathology Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-11 Completed Date: 1998-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0175411 Medline TA: Pathology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 374-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Wellington School of Medicine, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneurysm
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immunology,
pathology* Animals Arteriosclerosis / immunology, pathology Calcinosis / pathology Carotid Arteries / pathology* Female Macrophages / cytology Sheep Thrombosis / pathology Time Factors Tunica Intima / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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