Document Detail


Histological appearance of the synovium in early rheumatoid arthritis.
MedLine Citation:
PMID:  7939728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report reviews and discusses studies on the synovial fluid and biopsy specimens of synovial membrane obtained during the first 6 weeks of synovitis that evolved into rheumatoid arthritis (RA). Five previously unreported cases are described. Early changes in the microvasculature and synovial lining seem to antedate the classical chronic inflammation of established RA. Further characterization in the joint tissues in very early RA offers opportunities for identification of exogenous triggers and may allow more appropriate targeting of early therapy to potentially reversible aspects of pathogenesis.
Authors:
H R Schumacher; B B Bautista; R E Krauser; A K Mathur; E P Gall
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  23     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-27     Completed Date:  1994-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-10     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Rheumatoid / pathology*
Endothelium, Vascular / ultrastructure
Female
Humans
Male
Microscopy, Electron
Middle Aged
Synovial Fluid / cytology
Synovial Membrane / blood supply,  pathology*,  ultrastructure
Synovitis / pathology
Grant Support
ID/Acronym/Agency:
AR 07062/AR/NIAMS NIH HHS; AR 40525/AR/NIAMS NIH HHS; AR 40770/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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