Document Detail

Histological Quantification of Astrocytosis after Cerebral Infarction: A Systematic Review.
MedLine Citation:
PMID:  23311713     Owner:  NLM     Status:  Publisher    
Abstract Accurate histological quantification of astrocytosis after cerebral infarction is needed as this process may affect, and be affected by, many potential restorative treatments under investigation. We performed a systematic review to determine the most reliable histological method reported for measurement of post-infarction astrocytosis. We found reports of multiple techniques to quantify various parameters of immunohistochemical staining for the astrocyte marker glial fibrillary acidic protein on photomicrographs with several software packages. We found no studies directly comparing techniques. We conclude that the reported methods seem reasonable, but the descriptions were often insufficiently detailed to allow for replication, and the lack of comparison data makes the best method unclear. Further research is needed to optimize the analysis of this important tissue outcome after cerebral infarction.
Peter J Ostergaard; Matthew B Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  The International journal of neuroscience     Volume:  -     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Both authors are affiliated with the University of Wisconsin Department of Neurology.
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