Document Detail

Histological presence of Helicobacter pylori bacteria in the trabeculum and iris of patients with primary open-angle glaucoma.
MedLine Citation:
PMID:  22094712     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the role of Helicobacter pylori in primary open-angle glaucoma (POAG) pathophysiology by detecting its presence in eye biopsies of POAG patients during trabeculectomy.
PATIENTS AND METHODS: Fifty-one consecutive patients who underwent trabeculectomy for POAG not responsive to antiglaucoma therapy, and 35 consecutive anemic controls were examined for H. pylori presence mainly by gastric mucosa histology. In POAG patients, eye biopsies were also obtained and stained for H. pylori presence in situ.
RESULTS: Forty-three of 51 (84.3%) POAG patients and 17 of 35 (48.6%) controls were tested H. pylori positive (p = 0.0004). In 5 H. pylori-positive POAG patients, H. pylori bacteria were identified in the trabeculum and iris specimens.
CONCLUSION: For the first time, H. pylori bacteria have been detected histologically in eye biopsies of POAG patients.
Christos Zavos; Jannis Kountouras; Georgios Sakkias; Ioannis Venizelos; Georgia Deretzi; Stergios Arapoglou
Publication Detail:
Type:  Journal Article     Date:  2011-11-15
Journal Detail:
Title:  Ophthalmic research     Volume:  47     ISSN:  1423-0259     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-29     Completed Date:  2012-05-18     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  150-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Coloring Agents / diagnostic use
Glaucoma, Open-Angle / microbiology*,  pathology
Helicobacter Infections / diagnosis*
Helicobacter pylori / isolation & purification*
Iris / microbiology*
Middle Aged
Oxazines / diagnostic use
Trabecular Meshwork / microbiology*,  pathology
Reg. No./Substance:
0/Benzoxazines; 0/Coloring Agents; 0/Oxazines; 18472-89-4/cresyl violet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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