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Histological Findings in Unclassified Sudden Infant Death, including Sudden Infant Death Syndrome.
MedLine Citation:
PMID:  23331080     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To study histological variations and abnormalities in Unclassified Sudden Infant Death (USID) including Sudden Infant Death Syndrome (SIDS) in The Netherland. Design: two hundred Dutch USID cases between 1984 and 2005 were identified. The histology slides and autopsy reports of 187 cases were available for systematic review, including brain autopsy in 135 cases. Results: An explanation for the cause of death of 19 patients (10,2%) was found. Twelve had bronchopneumonia, three showed extensive aspiration, two had signs of a metabolic disorder, one had sepsis, and one had meningitis. Frequent non-specific findings were; congestion (66%), oedema (47%), small haemorrhages (18%) and lymphoid aggregates (51%) in the lungs; congestion of the liver (23%); asphyctic bleeding in the kidney (44%), adrenal gland (23%), and thymus (17%). Statistical associations were found for infection with starry sky macrophages in the thymus (p=0,004), with calcification (p=0,023), or with debris in the Hassal's corpuscles (p=0,034). Conclusion: in this study, in 10,2% of cases the histological findings were incompatible with SIDS or USID. Furthermore, several frequent non-specific histological findings in the thymus that point towards an infection were found.
Authors:
Germaine Liebrechts-Akkerman; Judith Bovée; Liliane C D Wijnaendts; Ann Maes; Peter J G Nikkels; Ronald R de Krijger
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a ErasmusMC, pathology.
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