| Histologic and ultrastructural analysis of melasma after fractional resurfacing. | |
| | |
MedLine Citation:
|
PMID: 18306153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVE: Fractional photothermolysis is a popular treatment option for photodamaged skin and other cutaneous conditions. Recently, successful improvement in melasma has been achieved with this laser system. We undertook this study to evaluate the ultrastructural changes associated with fractional laser treatment of melasma. STUDY DESIGN/MATERIALS AND METHODS: Ten subjects with skin types III and IV and a clinical diagnosis of epidermal melasma were treated with a 1,550-nm erbium:glass laser delivering light in a fractional manner (Fraxel SR 750, Reliant Technologies, Inc., Mountain View, CA) every 2 weeks for a total of four sessions. Biopsies were obtained from all subjects both before treatment and at 3 months following the final treatment. All biopsies were analyzed by light and electron microscopy for treatment-induced changes. In addition, a secondary endpoint of the study was to assess for clinical improvement in melasma following fractional resurfacing. This assessment was performed by the investigator using pre- and post-treatment photographs. RESULTS: Light microscopy on post-treatment specimens showed a relative decrease in melanocytes compared to the pre-treatment ones. Post-treatment electron microscopy revealed fewer melanocytes and a relative absence of melanin in the surrounding keratinocytes compared to pre-treatment specimens. In addition, six subjects with skin type III were determined to have good improvement, whereas four subjects with skin type IV had fair improvement, as assessed by the investigator. CONCLUSION: Post-treatment ultrastructural changes are consistent with an elimination process and may help to explain clinical improvement following laser treatment. |
| | |
Authors:
|
David J Goldberg; Alexander L Berlin; Robert Phelps |
Related Documents
:
|
17535223 - Rapid, severe repigmentation of congenital melanocytic naevi after curettage and dermab... 8851643 - Light therapy in patients with rapid cycling bipolar disorder: preliminary results. 2944573 - Aminoglutethimide and medroxyprogesterone acetate in the treatment of patients with adv... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Lasers in surgery and medicine Volume: 40 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-03-04 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
|
Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
|
Skin Laser & Surgery Specialists of NY/NJ, New York, New York, USA. drdavidgoldberg@drdavidgoldberg.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Dose Fractionation* Face Female Follow-Up Studies Humans Laser Therapy / methods* Melanocytes / ultrastructure Melanosis / pathology*, surgery* Prospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of t...
Next Document: Treatment of resistant tattoos using a new generation Q-switched Nd:YAG laser: influence of beam pro...