| Histologic studies on the nephrotic syndrome in the elderly. | |
| | |
MedLine Citation:
|
PMID: 3433283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Renal histopathology in 87 patients, aged over 60, with nephrotic syndrome were studied. In 57 patients diagnosed as primary glomerular disease, membranous glomerulonephritis (MGN) was of the most common histologic type (52.6% of the cases), and mesangial proliferative glomerulonephritis (21.1%), membranoproliferative glomerulonephritis (12.3%) and minimal change (12.3%) were the other types of primary glomerular disease. In the remaining 30 patients, nephrotic syndrome resulted from secondary glomerular diseases including diabetic nephropathy and renal amyloidosis. In comparison with the nephrotic syndrome of younger age group (669 cases, younger than 60 years of age), the incidence of MGN, diabetes and amyloidosis were significantly higher in the elderly. In contrast with unfavorable prognosis of diabetic nephropathy and amyloidosis, most cases of MGN and minimal change recovered from the nephrotic state with steroid treatment even in the elderly. Thus, a statistical finding that the prognosis of senile nephrotic syndrome is unfavorable as a whole, appears to be ascribable to the increased incidence of secondary glomerular diseases rather than to "aging" itself. The present results that the incidence of diabetic nephropathy was high and the outcome of MGN was favorable in the elderly, taken together with the results from other studies in Japan, are fairly different from the results of similar studies in the Western world. |
| | |
Authors:
|
H Sato; T Saito; T Furuyama; K Yoshinaga |
Related Documents
:
|
7177283 - Massive pulmonary embolism occurring with corticosteroid and diuretics therapy in a min... 7923963 - Combined treatment with cyclophosphamide and prednisolone can induce remission of nephr... 9681843 - Pathology of men-1: morphology, clinicopathologic correlations and tumour development. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Tohoku journal of experimental medicine Volume: 153 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1987 Nov |
Date Detail:
|
Created Date: 1988-03-18 Completed Date: 1988-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 259-64 Citation Subset: IM |
Affiliation:
|
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Hormones
/
therapeutic use Aged Aged, 80 and over Aging / pathology* Female Glomerulonephritis / pathology Humans Kidney / pathology* Male Nephrotic Syndrome / drug therapy, pathology* Prognosis |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphology of mouse embryo cultured in a newly established culture system using collagen gel layer.
Next Document: Histogenesis and characterization of minimal bronchogenic carcinoma observed in heavy smokers.