Document Detail


Histologic placental lesions in women with recurrent preterm delivery.
MedLine Citation:
PMID:  15901265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to evaluate whether particular placental histopathology lesions are associated with recurrent preterm birth. METHODS: We analyzed a database of 413 consecutive singleton pregnancies delivered at <32 weeks with past reproductive history available. After the exclusion of nulliparous women, the pregnancies were divided according to the obstetrical history into group 1 (n = 328), women without prior preterm delivery (PTD); group 2 (n = 49), women with one prior preterm childbirth; and group 3 (n = 36), women with > or =2 prior preterm deliveries. Demographic and clinical variables were compared among the three groups by using Kruskal-Wallis test and chi-square test for trend. Finally, the individual placental lesions (i.e. 42 lesions of acute or chronic inflammation, uteroplacental vascular pathology, and intraplacental villous lesions) were correlated with the number of prior preterm deliveries by using regression analysis. A two-tailed P < 0.05 was considered significant. RESULTS: No differences were found among the three groups in demographic or clinical variables. Regression analysis of scored placental lesions corrected for gestational age at delivery showed that the number of prior preterm deliveries was correlated only with chronic marginating choriodeciduitis (correlation coefficient = 0.13; P = 0.01) and acute choriodeciduitis (correlation coefficient = 0.14; P = 0.008). CONCLUSIONS: Among women delivered at <32 weeks, those with prior preterm birth have histologic findings compatible with acute or chronic inflammatory involvement of the uterine cavity, suggesting that a prepregnancy endometrial infection rather than an ascending intrapregnancy pathway may be responsible for some recurrences of PTD.
Authors:
Alessandro Ghidini; Carolyn M Salafia
Related Documents :
18355785 - A comparison of speculum and nonspeculum collection of cervicovaginal specimens for fet...
12889585 - What we have learned about the predictors of preterm birth.
9397115 - Duration of pregnancy after carbon dioxide laser conization of the cervix: influence of...
8169935 - Parenteral nutrition during pregnancy. lack of association with idiopathic preterm labo...
10849295 - Mitochondrial dna (mtdna) reveals that female bechstein's bats live in closed societies.
8636265 - Clinical performances of galactosyl hydroxylysine, pyridinoline, and deoxypyridinoline ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  84     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-06-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA. alessandro.ghidini@inova.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
District of Columbia / epidemiology
Female
Gestational Age
Humans
Infant, Newborn
Male
Medical Records
New York City / epidemiology
Obstetric Labor, Premature / epidemiology*,  etiology,  pathology
Parity
Placenta Diseases / complications*,  pathology
Pregnancy
Pregnancy Outcome
Recurrence
Regression Analysis
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Progesterone supplementation for preventing preterm birth: a systematic review and meta-analysis.
Next Document:  Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor:...