Document Detail


Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia.
MedLine Citation:
PMID:  20709464     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tularemia is a rare zoonotic disease caused by Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current report is to document the utility of applying several diagnostic tools, including immunohistochemistry, electron microscopy, microbiology and molecular biology in confirming the diagnosis of pulmonary tularemia, particularly in convalescing cases (up to 3 weeks postpresentation) and after antibiotic therapy. Our study demonstrates the usefulness of microbiological studies followed by morphological evaluation and the limitation of the molecular biology analysis of posttherapy samples.
Authors:
Paula Navarro; Maria L Garcia-Moliner; James H McMahon; Sam R Telford; Driss Zoukhri; Joseph Alroy
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Publication Detail:
Type:  Journal Article     Date:  2010-08-14
Journal Detail:
Title:  Pathology, research and practice     Volume:  207     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA.
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