Document Detail

Histologic and histomorphometric results of three bone graft substitutes after sinus augmentation in humans.
MedLine Citation:
PMID:  21046419     Owner:  NLM     Status:  In-Data-Review    
The aim of this study was to compare the histological behavior of three bone graft materials placed in human. The comparison was made among Bio-Oss® (BO), Engipore® (EP), and PepGen P-15® (P-15). Five biopsies for each group of biomaterial, retrieved 6 months after sinus lift augmentation, were analyzed. The investigation was carried out using light microscope (LM), scanning electron microscope (SEM) with an energy dispersive spectrometer (EDS), and circularly polarized light microscope (CPLM). Under LM, the amount of newly formed bone was significantly higher in BO than P-15 (P < .05), while the amount of residual graft material was significantly higher in P-15 than BO (P < .05). The extension of marrow spaces was significantly higher in EP than both BO and P-15 (P < .05). SEM-EDS analysis showed a Ca/P ratio of 1.8 for BO, 2.2 for EP, and 1.5 for P-15. Under CPLM, BO showed no significant difference for transverse (18.4 ± 2.7%) and longitudinal (16.3 ± 1.8%) bone collagen fibers (P = .195); EP showed a significant difference between transverse (4 ± 0.7%) and longitudinal (7.6 ± 2.5%) bone collagen fibers (P = .015); finally, P-15 showed no significant difference for transverse (3.8 ± 1.6%) and longitudinal (4.9 ± 1.2%) bone collagen fibers (P = .279). No investigated biomaterial was completely resorbed, but all the residual particles demonstrated a close bone integration to form a hybrid tissue. BO particles appeared perfectly osseointegrated in the trabecular bone. EP showed a tendency to concentrate the bone apposition into the microporosities; P-15 particles appeared bridged by newly formed bone trabeculae.
Marzia Pettinicchio; Tonino Traini; Giovanna Murmura; Sergio Caputi; Marco Degidi; Carlo Mangano; Adriano Piattelli
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Publication Detail:
Type:  Journal Article     Date:  2010-11-03
Journal Detail:
Title:  Clinical oral investigations     Volume:  16     ISSN:  1436-3771     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  D    
Department of Oral Sciences, Nano and Biotechnologies, University of Chieti-Pescara, Via dei Vestini, 31, 66100, Chieti, Italy.
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