Document Detail

Histologic findings in recurrent HBV.
MedLine Citation:
PMID:  17051563     Owner:  NLM     Status:  MEDLINE    
1. The histopathologic presentation of hepatitis B (HB) infection in liver allografts is generally similar to that seen in the nonallografts. 2. An atypical pattern of recurrent HB, i.e., fibrosing cholestatic hepatitis (FCH) occurs in a small number of patients. These patients present with a severe cholestatic syndrome, which may clinically resemble acute or chronic rejection. 3. There are several other possible causes of acute and chronic hepatitis in liver allografts that may need to be considered. 4. Hepatitis B virus (HBV) infection in the liver allograft can easily be confirmed by performing immunohistochemical stains for hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg). The expression pattern of these HBV antigens varies and is sometimes helpful in determining whether the liver injury is mainly from the HBV or from other causes in coexistence with the HBV infection. 5. Histological grading of the necroinflammatory activity and staging of the fibrosis should only be applied when the changes are related to the recurrent HB. 6. The pathology of liver transplantation is complex; therefore, clinical correlations remain extremely important in arriving at the final and correct diagnosis.
Swan N Thung
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  12     ISSN:  1527-6465     ISO Abbreviation:  Liver Transpl.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2007-01-04     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S50-3     Citation Subset:  IM    
Copyright Information:
Copyright 2006 AASLD.
Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Acute Disease
Hepatitis B / pathology*
Hepatitis B, Chronic / pathology*
Liver Cirrhosis / epidemiology,  pathology

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