Document Detail

Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study.
MedLine Citation:
PMID:  19573659     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: The aims of this study are as follows: METHOD: From 1979 to 2003, 57 children have been operated by the Kasai procedure. Only 40 of these have had their portal plate removed for histologic examination. We divided the patients according to clinical outcome into a successful and a failure group and compared the histologic features of the portal plates in the 2 groups. Afterward, the portal plate histology from EHBA was compared with the porta hepatis area from patients dead from other causes. RESULTS: A significant difference between the success and the failure group was found with regard to the number of bile ducts, the maximal length measurable in any direction for bile duct structures, and the proliferation, but not for any type of diameter. The normal portal plate was different from the portal plate of children with biliary atresia by always having 2 large biliary structures and the cells being mucinous and columnar in the largest bile ducts. Only 1 of 4 normal portal plates showed signs of proliferation. There was no significant difference between the normal and the success group with respect to the number, maximal length, and proliferation of the bile ducts. A difference in the diameter between the normal group and the entire EHBA group was significant for the maximal internal diameter but not for the other types of diameter measurements. CONCLUSION: The present study shows the following:
Qazaz Mirza; Nina Kvist; Bodil Laub Petersen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  44     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1344-8     Citation Subset:  IM    
Department of Pathology, University Hospital of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
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MeSH Terms
Bile Ducts, Extrahepatic / abnormalities*,  pathology
Biliary Atresia / epidemiology,  pathology*,  surgery
Cause of Death / trends
Cell Proliferation
Denmark / epidemiology
Diagnosis, Differential
Portal System / pathology*
Portoenterostomy, Hepatic
Retrospective Studies
Survival Rate / trends

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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