Document Detail

Histologic evaluation of fetal brains following maternal pneumoperitoneum.
MedLine Citation:
PMID:  11727136     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to determine if maternal pneumoperitoneum with carbon dioxide (CO2) produces evidence of central nervous system (CNS) injury in preterm fetal guinea pigs. METHODS: Thirty pregnant guinea pigs at gestational day (GD) 45 were assigned at random to one of three treatment groups: anesthesia only, CO2 pneumoperitoneum (5 mmHg), or laparotomy. Dams were killed 3 or 5 days postprocedure and fetal brains (83 total) harvested and fixed for subsequent histopathologic evaluation. For comparative purposes, histologic features of fetal guinea pig brain injury were defined from examination of fetal brains harvested from an additional dam that underwent laparotomy with 20 min of uterine arterial occlusion. RESULTS: Carbon dioxide pneumoperitoneum did not increase maternal/fetal morbidity. No evidence of brain injury was found in fetuses from any of the treatment groups. CONCLUSION: Carbon dioxide pneumoperitoneum at 5 mmHg for 40 min in the pregnant guinea pig does not produce evidence of fetal brain injury.
M Garcia-Oria; A Ali; J D Reynolds; E Clary; A Gandsas; T Cummings; R L McMahon; S Bruch; M Fina; A Ko; S Eubanks
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Publication Detail:
Type:  Journal Article     Date:  2001-09-04
Journal Detail:
Title:  Surgical endoscopy     Volume:  15     ISSN:  1432-2218     ISO Abbreviation:  Surg Endosc     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-29     Completed Date:  2002-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1294-8     Citation Subset:  IM    
Department of Surgery, Duke University Medical Center, Endosurgery Research Laboratory, Durham, NC, 27710, USA.
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MeSH Terms
Brain / embryology*,  pathology*
Carbon Dioxide
Guinea Pigs
Pneumoperitoneum, Artificial / adverse effects*
Prenatal Exposure Delayed Effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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