Document Detail


Histologic evaluation of effect of thiocyanate topical application on hamster cheek pouch.
MedLine Citation:
PMID:  16758159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to investigate the effect of topical thiocyanate (SCN(-)) application on hamster cheek pouch mucosa. Sixty-six hamsters were divided into two groups. The test substance containing potassium thiocyanate was applied on the hamsters' cheek pouches at 55 mg/kg dosages. Cheek pouches were grossly examined after 12 weeks. Histometric evaluation included height measurements from the epithelium without stratum corneum, stratum corneum, and full epithelium. Clear cells frequency was compared between groups. Results were analyzed using Student's t test. The experimental group showed a lower height of the stratum corneum (p=0.035) and higher frequency of clear cells (p<0.001). There was no height difference for the epithelium without stratum corneum (p=0.677) and full epithelium (p=0.904) between groups. SCN(-) promotes no gross alterations on hamsters' cheek pouch and does not induce dysplastic features at the epithelium or inflammation at the connective tissue. The ion promotes histologic alterations on mucosa that need to be investigated in further studies.
Authors:
Fernanda Gonçalves Salum; Karen Cherubini; Maria Antonia Zancanaro de Figueiredo; Milton de Oliveira Amado; Eloni Terezinha Rodrigues; Liliane Soares Yurgel
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Publication Detail:
Type:  Journal Article     Date:  2006-06-07
Journal Detail:
Title:  Clinical oral investigations     Volume:  10     ISSN:  1432-6981     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  D    
Affiliation:
Department of Stomatology, São Lucas Hospital PUCRS, Porto Alegre, Brazil. fesalum@terra.com.br
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Cheek
Cricetinae
Epithelium / drug effects
Mesocricetus
Mouth Mucosa / drug effects*
Random Allocation
Thiocyanates / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Thiocyanates; 333-20-0/potassium thiocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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