| Histologic evaluation of effect of thiocyanate topical application on hamster cheek pouch. | |
MedLine Citation:
|
PMID: 16758159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was conducted to investigate the effect of topical thiocyanate (SCN(-)) application on hamster cheek pouch mucosa. Sixty-six hamsters were divided into two groups. The test substance containing potassium thiocyanate was applied on the hamsters' cheek pouches at 55 mg/kg dosages. Cheek pouches were grossly examined after 12 weeks. Histometric evaluation included height measurements from the epithelium without stratum corneum, stratum corneum, and full epithelium. Clear cells frequency was compared between groups. Results were analyzed using Student's t test. The experimental group showed a lower height of the stratum corneum (p=0.035) and higher frequency of clear cells (p<0.001). There was no height difference for the epithelium without stratum corneum (p=0.677) and full epithelium (p=0.904) between groups. SCN(-) promotes no gross alterations on hamsters' cheek pouch and does not induce dysplastic features at the epithelium or inflammation at the connective tissue. The ion promotes histologic alterations on mucosa that need to be investigated in further studies. |
Authors:
|
Fernanda Gonçalves Salum; Karen Cherubini; Maria Antonia Zancanaro de Figueiredo; Milton de Oliveira Amado; Eloni Terezinha Rodrigues; Liliane Soares Yurgel |
Related Documents
:
|
10594759 - Barrier formation in the human fetus is patterned. 7904869 - Birthmarks and congenital skin lesions in chinese newborns. 8721169 - Extramucosal pyloromyotomy by laparoscopy. 8893949 - Community-acquired pseudomonas aeruginosa infection in an infant. 714579 - Skin oxygen permeability in premature infants. 11993059 - A premature infant with skin injury successfully treated with bilayered cellular matrix. 17667409 - Facial attractiveness: visual impact of symmetry increases significantly towards the mi... 20815729 - Mothers' and fathers' reports of stress in families of infants with and without single-... 14629529 - Evaluation of standardized versus individualized total parenteral nutrition regime for ... |
Publication Detail:
|
Type: Journal Article Date: 2006-06-07 |
Journal Detail:
|
Title: Clinical oral investigations Volume: 10 ISSN: 1432-6981 ISO Abbreviation: Clin Oral Investig Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-14 Completed Date: 2006-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9707115 Medline TA: Clin Oral Investig Country: Germany |
Other Details:
|
Languages: eng Pagination: 211-5 Citation Subset: D |
Affiliation:
|
Department of Stomatology, São Lucas Hospital PUCRS, Porto Alegre, Brazil. fesalum@terra.com.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Animals Cheek Cricetinae Epithelium / drug effects Mesocricetus Mouth Mucosa / drug effects* Random Allocation Thiocyanates / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Thiocyanates; 333-20-0/potassium thiocyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Purification, characterization, and gene cloning of 4-hydroxybenzoate decarboxylase of Enterobacter ...
Next Document: Double line sign: a helpful sonographic sign to detect occult fractures of the proximal humerus.