Document Detail

Histologic evaluation of a cornea in a patient with apolipoprotein A-I deficiency.
MedLine Citation:
PMID:  18362673     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency. METHODS: A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically. RESULTS: There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 microm. These histologic properties suggest that the small vesicles are lipid droplets. CONCLUSIONS: Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.
Yasuhiro Osakabe; Shiro Amano; Shima Fukuoka; Satoru Yamagami
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cornea     Volume:  27     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-3     Citation Subset:  IM    
Department of Pathology, Tokyo Medical University, Tokyo, Japan.
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MeSH Terms
Apolipoprotein A-I / deficiency*,  genetics
Cornea / ultrastructure*
Corneal Opacity / etiology*,  pathology*,  surgery
Frameshift Mutation
Keratoplasty, Penetrating
Reg. No./Substance:
0/Apolipoprotein A-I

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