Document Detail

Histologic effects of collagen-filled interlocking detachable coils in the ablation of experimental aneurysms in swine.
MedLine Citation:
PMID:  8733957     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the histologic changes produced by platinum microcoils with an inner core of cross-linked bovine collagen in experimentally induced aneurysms in swine, and to assess the feasibility of the system for the delivery of the collagen. METHODS: Bilateral pouch aneurysms were created in the side wall of the common carotid artery in seven barnyard pigs. Eight aneurysms were treated with coils designed with an interlocking detachment mechanism: in four of these, the coils had an inner core of collagen; in the other four, the platinum microcoils had a similar design but without the collagen mandrel. The packing density of the coils within the aneurysm was approximately the same for both types of coils. The other six aneurysms were left untreated and served as controls. Angiograms were obtained at the time of treatment (2 weeks after the aneurysms were created) and at 1, 4, and 8 weeks after treatment. All animals were killed 8 weeks after the treatment (10 weeks after the aneurysms were created). Arteries and aneurysms were resected en bloc and fixed for histopathologic study. RESULTS: The interlocking detachment mechanism worked well. Little difference was noted between the two types of coils in their ability to effect complete aneurysmal thrombosis (three of four aneurysms treated with collagen-core coils and two of four aneurysms treated with conventional coils). The collagen-core coils stimulated new collagen formation in areas proximal to the coils, and more fibroblasts were noted near the collagen-core coils than near the conventional coils. CONCLUSION: Local fibroblast proliferation and collagen production were stimulated by heterologous cross-linked collagen embedded in micro-coils in this experimental model. Such biologic stimulation holds promise for improving the endovascular cure rate of aneurysms in humans.
R C Dawson; G G Shengelaia; A F Krisht; G D Bonner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  17     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-8     Citation Subset:  IM    
Department of Radiology, Emory University, Atlanta, Ga, USA.
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MeSH Terms
Aneurysm / pathology,  radiography,  therapy*
Carotid Artery Diseases / pathology,  radiography,  therapy*
Carotid Artery, Common / pathology,  radiography
Cell Division
Collagen / biosynthesis,  therapeutic use*
Cross-Linking Reagents
Embolization, Therapeutic / instrumentation*
Equipment Design
Feasibility Studies
Fibroblasts / pathology
Follow-Up Studies
Reg. No./Substance:
0/Cross-Linking Reagents; 7440-06-4/Platinum; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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