| Histologic development of cervical ectopy: relationship to reproductive hormones. | |
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MedLine Citation:
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PMID: 10821596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Cervical ectopy has been proposed as a risk factor for chlamydial infection, HIV, and other sexually transmitted diseases (STDs). Ectopy is a histologic phenomenon resulting from a complex interplay of morphologic and hormonal processes. Reproductive hormones influence the production of ectopy during late fetal life, puberty, pregnancy, and with use of oral contraceptives. Ectopy is modified over time by squamous metaplasia and epitheliazation, low pH, trauma, and possibly by cervical infection. STUDY DESIGN: The authors review the histologic development of ectopy from late fetal life to menopause to understand STD risk. RESULTS: Ectopy is often assessed and quantified by direct, unaided observation during speculum examinations. This method may result in inaccurate estimates and misclassification with the transformation zone. CONCLUSION: Valid, reproducible measures of ectopy are necessary for epidemiologic studies to examine the impact of exogenous hormonal contraceptives on the development of ectopy and on potential infection risk. |
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Authors:
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D L Jacobson; L Peralta; N M Graham; J Zenilman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Sexually transmitted diseases Volume: 27 ISSN: 0148-5717 ISO Abbreviation: Sex Transm Dis Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-08-17 Completed Date: 2000-08-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7705941 Medline TA: Sex Transm Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cervix Uteri / abnormalities, drug effects, pathology* Contraceptives, Oral / pharmacology Epithelium / drug effects, pathology Female Gonadal Steroid Hormones / pharmacology* Humans Middle Aged Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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U19A138533//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Gonadal Steroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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