Document Detail

Histologic comparison of the pulsed dye laser and copper vapor laser effects on pig skin.
MedLine Citation:
PMID:  2263154     Owner:  NLM     Status:  MEDLINE    
Albino pig skin was exposed to the copper vapor (CVL) and flash-lamp pulsed dye (PDL) lasers at 578 nm with a 3 mm diameter spotsize over a range of fluences until purpura and whitening were first established. The total irradiation time was the parameter that was varied in order for the CVL to reach the desired fluence. The lowest fluence producing each clinical endpoint was designated the threshold fluence: 34 J/cm2 was required to produce purpura using the CVL compared to 7.5 J/cm2 with the PDL laser. Histologically, skin exposed to purpura fluences from the CVL revealed the presence of constricted, disrupted papillary dermal blood vessels with trapped RBC's within them which were unlike those exposed to PDL where the irradiated vessels were dilated and packed with masses of intravascular agglutinated RBC's. The whitening threshold fluences for the CVL and PDL lasers were 67 J/cm2 and 29 J/cm2, respectively. Streaming of epidermal cells and dermal collagen denaturation were observed in CVL irradiated skin, compared to occasional dyskeratotic epidermal cells and focal dermal collagen denaturation following PDL exposure. The mechanisms responsible for the clinical and histologic changes produced by the two laser systems are discussed.
O T Tan; T J Stafford; S Murray; A K Kurban
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  10     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-04     Completed Date:  1991-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  551-8     Citation Subset:  IM    
Department of Dermatology, Boston University Medical Center, MA.
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MeSH Terms
Blood Vessels / pathology
Collagen / analysis
Epidermis / pathology
Laser Therapy / methods*
Skin / blood supply,  pathology*,  radiation effects,  surgery
Grant Support
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